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Wednesday, July 22, 2020 | History

4 edition of COX-2 blockade in cancer prevention and therapy found in the catalog.

COX-2 blockade in cancer prevention and therapy

COX-2 blockade in cancer prevention and therapy

  • 356 Want to read
  • 32 Currently reading

Published by Humana Press in Totowa, N.J .
Written in English

    Subjects:
  • Cancer -- Chemoprevention,
  • Cyclooxygenase 2 -- Inhibitors -- Therapeutic use,
  • Nonsteroidal anti-inflammatory agents

  • Edition Notes

    Includes bibliographical references and index.

    Other titlesCOX-two blockade in cancer prevention and therapy.
    Statementedited by Randall E. Harris.
    SeriesCancer drug discovery and development
    ContributionsHarris, Randall E.
    Classifications
    LC ClassificationsRC268.15 .C69 2003
    The Physical Object
    Paginationx, 371 p. :
    Number of Pages371
    ID Numbers
    Open LibraryOL21661315M
    ISBN 101588290107
    LC Control Number2002068761
    OCLC/WorldCa49895216

    2. COX-2 expression in precancerous and cancerous lesions of the head and neck including oral cavity. Initial observations for overexpression of COX-2 in precancerous and cancerous lesions were done in colorectal adenomas and carcinomas 6, 7, was based on the epidemiological studies that the relative risk for colorectal cancer was reduced by a % in persons who regularly use aspirin Cited by:   Abou-Issa HM, Alshafie GA, Harris RE: Chemoprevention of breast cancer by nonsteroidal anti-inflammatory drugs and selective COX-2 blockade in animals. COX-2 Blockade in Cancer Prevention and Therapy. Edited by: Harris RE. Cited by:

      Cancer prevention with Cox-2 inhibitors hampered by cardiovascular toxicity Although Cox-2 inhibitors can prevent premalignant polyps, they . form of adjunct therapy, COX-2 inhibitors also increased the sensitivity of tumor cells to other anticancer agents and radiation [16]. This synergy promotes its use in combined regimes. Familial adenomatous polyposis (FAP) is a genetic premalignant disease of the colon. Blockade of COX-2 either by gene deletion or by phar-.

      Since these tumors can be treated by COX-2 inhibitors to improve T-cell invasion, another class of drugs called anti-PD1 drugs can be used to treat these tumors in combination with COX-2 inhibitors. “Our studies provide a clear rationale to test, in the clinics, combinations of anti-PD1 immunotherapy and COX-2 inhibitors,” Van den Eynde said. Books. Harris RE. Global Epidemiology of Cancer, Jones & Bartlett, Harris RE. Epidemiology of Chronic Disease: Global Perspectives, Jones & Bartlett, Harris RE. Inflammation in the Pathogenesis of Chronic Diseases: the COX-2 Controversy, Springer, Harris RE. COX-2 Blockade in Cancer Prevention and Therapy. Humana Press,


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COX-2 blockade in cancer prevention and therapy Download PDF EPUB FB2

Comprehensive and up-to-date, COX-2 Blockade in Cancer Prevention and Therapy demonstrates how COX-2 inhibitors and other NSAIDs reduce the risk of most cancers and provides cancer investigators today with a clear and authoritative guide to the development of novel agents with significant antineoplastic : Randall E.

Harris. In COX-2 Blockade in Cancer Prevention and Therapy, a panel of leading experts chronicles the evidence for the chemopreventive and therapeutic effects of cyclooxygenase-2 (COX-2) inhibitors against virtually all forms of cancer and presents exciting new opportunities for the use of COX-2 blockade in their prevention and cturer: Humana.

Comprehensive and up-to-date, COX-2 Blockade in Cancer Prevention and Therapy demonstrates how COX-2 inhibitors and other NSAIDs reduce the risk of most cancers and provides cancer investigators today with a clear and authoritative guide to the development of novel agents with significant antineoplastic properties.

COX-2 Blockade in Cancer Prevention and Therapy Edited by Randall E. Harris (The Ohio State University). Humana Press Inc., Totowa, NJ.

x Author: Lars Bohlin. Request PDF | COX-2 Blockade in Cancer Prevention and Therapy | COX-2 Blockade in Cancer Prevention and Therapy chronicles the evidence and presents Author: Randall Harris.

Abstract. Multiple lines of evidence suggest that aberrant induction and upregulation of the prostaglandin cascade play a significant role in colon and mammary carcinogenesis, and that blockade of this process has strong potential for intervention and cancer chemoprevention of these by: 1.

CLICK HERE FOR MEDICAL BOOKS FREE DOWNLOAD FOR THOSE MEMBERS WITH BLOCKED DOWNLOAD LINKS. Cox-2 Blockade in Cancer Prevention and Therapy Oncology. Jan 14 Occupational Therapy (33) Oncology (1,) Ophthalmology (). Results of meta‐analyses of NSAIDs (primarily aspirin and ibuprofen) and cancer are included for comparison.

Findings are generalized, molecular mechanisms of carcinogenesis reviewed and future perspectives are discussed on the exciting possibilities for COX‐2 blockade by ibuprofen and related compounds in cancer prevention and : Randall E.

Harris. PGE 2 production in preclinical breast and colon cancer models was tightly controlled by cyclooxygenase-2 (COX-2) expression, and COX-2 inhibition augmented VEGF pathway blockade Cited by:   COX-2 Blockade in Cancer Prevention and Therapy chronicles the evidence and presents exciting new op­ portunities for the use of cyclooxygenase-2 (COX-2) blockade in the prevention and treatment of cancer.

The text is divided broadly into five : Humana Press. COX-2 Blockade in Cancer Prevention and Therapy chronicles the evidence and presents exciting new opportunities for the use of COX-2 inhibiting agents in the prevention and treatment of cancer.

The combination of COX-2 inhibitors with radiation or other anti-cancer or cancer prevention drugs may reduce their side effects in future cancer prevention and treatment.

Recent progress in the treatment and prevention of cancers of the colon, esophagus, lung, bladder, breast and prostate with NSAIDs, especially COX-2 inhibitors, is also. A comprehensive treatise of COX-2, inflammation and disease Offers a spell-binding look at the COX-2 controversy Details new and exciting findings on COX-2 blockade in cancer prevention and therapy as well as the prevention of Alzheimer’s disease and other neurodegenerative conditions.

COX-2 Blockade in Cancer Prevention and Therapy chronicles the evidence and presents exciting new op­ portunities for the use of cyclooxygenase-2 (COX-2) blockade in the prevention and treatment of cancer. The text is divided broadly into five : Humana Press. -Lancet Oncology"This comprehensive and up-to-date monograph demonstrates how COX-2 inhibitors and other NSaids reduce the risk of most cancers and provides cancer investigators by a clear and authoritative guide leading to the development of novel angst with significant antineoplastic properties.".

COX-2 Blockade in Cancer Prevention and Therapy Autor Randall E. Harris. This book chronicles the evidence for the chemopreventive and therapeutic effects of cyclooxygenase-2 (COX-2) inhibitors against virtually all forms of cancer and presents exciting new opportunities for the use of COX-2 blockade i.

COX-2 Blockade in Cancer Prevention and Therapy (). Humana Press: New York, NY. Inflammation in the Pathogenesis of Chronic Diseases: The COX-2 Controversy (). Coaxing cancer control by modulating COX-2 Rajan P.

Kulkarni Department of Dermatology and Center for Early Cancer Detection and Research (CEDAR), Knight Cancer Institute, Oregon Health and Science University, Portland, ORUSA; Operative Care Division, VA Portland Health Care System, Portland, OR: Rajan P.

Kulkarni. COX-2 Blockade in Cancer Prevention and Therapy. Humana Press, Totowa, NJ; pp. 85– Harris RE, Alshafie GA, Abou-Issa H, Seibert K. Chemoprevention of breast cancer in rats by Celecoxib, a specific cyclooygenase-2 (COX-2) inhibitor. Cancer Res. ; – Harris RE, Robertson FM, Farrar WB, Brueggemeier by: Get this from a library.

COX-2 blockade in cancer prevention and therapy. [Randall E Harris;] -- The discovery that aspirin and other nonsteroidal anti-inflammatory drugs (NSAIDs) have notable antineoplastic properties has revolutionized cancer research.

In COX-2 Blockade in Cancer Prevention. Harris RE. COX-2 blockade in cancer prevention and therapy: widening the scope of impact. In: Harris RE, editor. COX-2 Blockade in Cancer Prevention and Therapy. Totowa, NJ: Humana Press; pp. –Cited by: Disease prevention is one area that both public and governmental agencies strongly support owing to its potential for an improved lifestyle and a reduction in health care costs.

In this review, we focus on the clinical development of one target for cancer prevention, the COX-2 enzyme. This provides an excellent example of how basic research in biochemistry and pharmacology can lead to Cited by: COX-2 – A Novel Target for Reducing Tumor Angiogenesis and Metastasis Dual therapy with axitinib and celecoxib prevented the outgrowth of spontaneous breast cancer metastasis in the lung.